Synthesis    Msc Abstract

New methods for synthesis of Azoles and Azines from Nitrles    Msc Abstract

Utility of nitriles in Heterocyclic Synthesis : some new approaches for synthesis of pyridazines and pyrimidines    Phd Abstract

FATEHIA, K. Mohamed., HADEER, M. Bakeer.,*MAHER, A., EL HASHASH andAHMED, M. EL-BETAR. Studies on 2-substituted 6, 8-dibromo-4(H)-3,1 Benzoxazin-4-one Chemistry department, Faculty of Science, Fayoum University, EL- Fayoum, Egypt.   

Mohamed A. E. Khalifa, Gamal H. Tamam and Hadeer M. Bakeer, Activated Nitriles in Heterocyclic Chemistry, A novel synthesis of pyridones, pyrazolo [1,5 – a] pyrimidines and Pyrazolo [1,5 – b] oxazines .Arch. Pharm. ( Wein heim ) , 317 , ( 1984 ) , 198 – 202 .

Said A. S. Ghozlan, Mona H. Mohamed, Ahmed Y. Soliman and Hadeer M.Bakeer, Reactions with 3 – Oxo -2 – phenylhydrazonobutyronitrile :New Routes for the Synthesis of Pyridazines .Gazz. Chem, Ital., 119 , ( 1989 ) , 95 – 97 .

A. Y. Soliman and Hadeer M. Bakeer, Nitriles in Heterocyclic Synthesis : Studies on Ethyl 3 – amino – 4,4 – dicyano – 3 – butenoate .Chinese J. Chem., 9 ,( 1991 ),461 – 466.

A. Y. Soliman, S. El – Nagdy, H. M. Bakeer and M. M. Moustafa and R. M. Saleh,Synthesis of n – Butyl 2 ( H ) – oxonaphtho [1,2 – b] – pyran – 4 – acetate and n – Butyl 3 ( H ) - oxonaphtho [1,2 – b] – pyran -1 – acetate and Their Reactions. Indian J. Chem. , 29 ( B ) , ( 1990 ) , 239 – 243 .

S. El – Nagdy, A. Y. Soliman, M. R. Mahmoud, R. Saleh and H. M. Bakeer, Synthesis and Some Reactions of New 3, 1 – Benzoxazin – 4 – one Derivatives and Their Biological Activity . Indian J. Chem. , 29 ( B ) , ( 1990 ) , 347 – 351 .

R. M. Saleh, A. Y. Soliman, S. El – Nagdy, H. M. Bakeer and M. M. Moustafa, The Reactivity of Naphthopyran – 2 – one Derivatives Toward Nucleophilic and Electrophilic Reagents . Phosphorus, Sulfur and Silicon, 48 , ( 1990 ) , 258 – 288 .

M. R. Mahmoud, A. Y. Soliman, and H. M. Bakeer,Studies on Chromones and Xanthone Derivatives .Phosphorus, Sulfur and Silicon, 53 , ( 1990 ) , 135 – 143 .

A. Y. Soliman, H. M. Bakeer, M. A. Sayed, I. Islam and A. A. Mohamed, Some Reactions of 4 – Aryl – 1 ( 2H ) – Phthalazinones .Chinese J. Chem. , 8 , ( 1990 ) , 549 – 554 .

M. R. Mahmoud, A. Y. Soliman, and H. M. Bakeer, Synthesis and Some Reactions of Pyrimidine – 2 – thione Derivatives . Indian J. Chem. , 29 ( B ), ( 1990 ) , 830 – 835 .

A. Y. Soliman, M. EL – Kady, F. EL – Shahed, H. M. Bakeer and I. Mohey,Relative Reactivity of Benzopyranone and Isobenzofurodione in Isobenzofuro [4,5 – c ] Benzopyrantrione . J. Serb. Chem. Soc. , 55 ( 9 ) , ( 1990 ) , 501 – 508 .

A. F. El - Kafrawy, A. Y. Soliman, and H. M. Bakeer, F. K. Mohamed and M. Y. El – Kady, Synthesis and Comparative Study of Reactivities of ? - Lactone, Ester Group and Oxazinone Ring in Coumarin Derivatives Toward Carbon or Nitrogen Nucleophiles . Chinese J. Chem. , 8 , ( 1990 ) , 469 – 473 .

M. A. Sayed, I. Islam, A. A. Mohamed, A. Y. Soliman and H. M. Bakeer, Synthesis and Reactions of 4 – Aryl – 1 ( 2H ) – phthalazinones .Chinese J. Chem. , 9 , ( 1991 ) , 45 – 53 .

A. Y. Soliman, M. R. Mahmoud and H. M. Bakeer,Reaction with – 2 – Methyl – naphtho [1,2 – b] pyran – 4 – one and Related Substances . Acta Chim. Hung. , 128 ( 3 ) , ( 1991 ) , 345 – 354 .

A. Y. Soliman, A. F. El - Kafrawy, F. K. Mohamed and H. M. Bakeer and A. M. Abdel - Gawad, Synthesis and Some Reactions of 7 – Methyl coumarin – 4 – acetic acid .Indian J. Chem. , 30 ( B ) , ( 1991 ) , 477 – 481 .

Hadeer M. Bakeer,Conversion of 2 – Arylhydrazono – 3 – oxobutyronitrile and 2– Phenylhydrazono – ethylbenzoylacetate into Heterocyclic Compounds . J. Serb. Chem. Soc. , 57 ( 11 ) , ( 1992 ) , 725 – 730 .

A. F. El - Kafrawy, A. Y. Soliman, H. M. Bakeer, F. K. Mohamed and A. M. Abdel - Gawad, Synthesis of Some Coumarin Derivatives and Study of their Behavior Towards Carbon and Nitrogen Nucleophiles . Egyption J. Chem. , 35 ( 2 ) , ( 1992 ) , 253 – 263 .

S. El – Nagdy, A. Y. Soliman, Hadeer M. Bakeer and A. M. Youssef J. Cycloaddation Reaction on Naphthopyran - 2 – one Derivatives . Chem. Soc. Pakistan, 12 ( 3 ) , ( 1990 ) , 230 – 234 .

F. K. Mohamed and H. M. Bakeer, Synthesis and Reactions of 3 – Amino –6– [4– Chloro phenyl ] 6– hydro –2 – mercaptodihydropyrimidine . Bull. Fac. Sci. , Assiut Univ, 24 ( 1 - B ) , ( 1995 ) , 311 – 324 .

A. Y. Soliman, H. M. Bakeer and I. A. Attia, Heterocyclic Compounds from 3 – (4 – Phenyl ) benozyl propionic acid . Chinese J. Chem. , 14 ( 6 ) , ( 1996 ) , 532 – 540 .

Hadeer M. Bakeer,Electrochemical Evidence for Detection of Steric Hindrance in 1- [2 – Cyclo – hexyliden – 1 – one] – 2 – Ferrocenyl Ethylene . Contrasting Behavior in Solution and when Adsorbed on Highly Ordered Pyrolytic Graphite . Egypt. J. Chem. 46 ( 3 ) , ( 2003 ) , 527 – 536 .

Hadeer M. Bakeer,Conversion of 3 – Carbethoxy -4 – methyl Coumarin Derivatives into Several New Annelated Coumarin Derivatives . Chinese J. Chem. , 21 , ( 2003 ) , 1219 – 1223 .

G. H. Tamam, H. M. Bakeer, R. M. Abdel – Motalab and W. A. Arafa, J. Synthesis and Some Reactions of Coumarin – 3 - yl Crotononitrile Derivatives .Chin. Chem. , Soc. , 52 ( 6 ) , ( 2005 ) , 1191 – 1199 .

H. M. Bakeer,Studies on 3 – ( Substituted ) Coumarin Derivatives Toward Different Electrophiles and Nucleophiles . International J. Chem. , 17 ( 3 ) , ( 2007 ) , 197 – 204 .

R. M. Abdel – Motalab, H. M. Bakeer, G. H. Tamam and W. A. A. Arafa, Synthesis and some reactions of 4-(2- alkayl-2- arylhydrazono) – 2 – phenyloxazol -5- one Derivatives . Egypt J. Chem. , 50 (6) , ( 2007 ) , Accept. for publication (9/10/2007) .

H. M. Bakeer and F. K. Mohamed,Synthesis of some interesting New Heterocyclic Compounds Containing Coumarin Moiety. Egypt J. Chem. , 51 (3) , ( 2008 ) , Accept. for publication (9/12/2007) .

H. M. Bakeer, Facile and preparation of 3- functional Chromen -2- ones . Egypt J. Chem., 51 (3) ,( 2008 ), Accept. for publication (17/2/2008) .

Hadeer M. Bakeer, R. R. Kassab and E. A. Kassab,Electrochemical Analysis of Claisen Condensation of a Ferrocene Carrying Methylene – Active Side Chains with Oxo – Function Groups on Highly Ordered Pyrolytic Graphite .Egypt. J. Chem. 46( 2 ) , ( 2003 ) , 285 – 295 .

"New methods for synthesis of Azoles and Azines from Nitrles "

Activated Nitriles in Heterocyclic Chemistry, A novel synthesis of pyridones, pyrazolo [1,5 – a] pyrimidines and Pyrazolo [1,5 – b] oxazines . Mohamed A. E. Khalifa, Gamal H. Tamam and Hadeer M. Bakeer, Arch. Pharm. ( Wein heim ) , 317 , ( 1984 ) , 198 – 202 .

" Utility of nitriles in Heterocyclic Synthesis : some new approaches for synthesis of pyridazines and pyrimidines "

Reactions with 3 – Oxo -2 – phenylhydrazonobutyronitrile : New Routes for the Synthesis of Pyridazines . Said A. S. Ghozlan, Mona H. Mohamed, Ahmed Y. Soliman and Hadeer M.Bakeer, Gazz. Chem, Ital., 119 , ( 1989 ) , 95 – 97 .

Nitriles in Heterocyclic Synthesis : Studies on Ethyl 3 – amino – 4,4 – dicyano– 3 – butenoate . A.Y. Soliman and Hadeer M. Bakeer, Chinese J. Chem., 9 ,( 1991 ),461 – 466.

Synthesis of n – Butyl 2 ( H ) – oxonaphtho [1,2 – b] – pyran – 4 – acetate and n – Butyl 3 ( H ) - oxonaphtho [1,2 – b] – pyran -1 – acetate and Their Reactions. A. Y. Soliman, S. El – Nagdy, H. M. Bakeer and M. M. Moustafa and R. M. Saleh, Indian J. Chem. , 29 ( B ) , ( 1990 ) , 239 – 243 .

Synthesis and Some Reactions of New 3, 1 – Benzoxazin – 4 – one Derivatives and Their Biological Activity . S. El – Nagdy, A. Y. Soliman, M. R. Mahmoud, R. Saleh and H. M. Bakeer, Indian J. Chem. , 29 ( B ) , ( 1990 ) , 347 – 351 .

The Reactivity of Naphthopyran – 2 – one Derivatives Toward Nucleophilic and Electrophilic Reagents . R. M. Saleh, A. Y. Soliman, S. El – Nagdy, H. M. Bakeer and M. M. Moustafa, Phosphorus, Sulfur and Silicon, 48 , ( 1990 ) , 258 – 288 .

Studies on Chromones and Xanthone Derivatives . M. R. Mahmoud, A. Y. Soliman, and H. M. Bakeer, Phosphorus, Sulfur and Silicon, 53 , ( 1990 ) , 135 – 143 .

Some Reactions of 4 – Aryl – 1 ( 2H ) – Phthalazinones . A. Y. Soliman, H. M. Bakeer, M. A. Sayed, I. Islam and A. A. Mohamed, Chinese J. Chem. , 8 , ( 1990 ) , 549 – 554 .

Synthesis and Some Reactions of Pyrimidine – 2 – thione Derivatives . M. R. Mahmoud, A. Y. Soliman, and H. M. Bakeer, Indian J. Chem., 29 ( B ), ( 1990 ) , 830 – 835 .

Relative Reactivity of Benzopyranone and Isobenzofurodione in Isobenzofuro [4,5 – c ] Benzopyrantrione . A. Y. Soliman, M. EL – Kady, F. EL – Shahed, H. M. Bakeer and I . Mohey, J. Serb. Chem. Soc. , 55 ( 9 ) , ( 1990 ) , 501 – 508 .

Synthesis and Comparative Study of Reactivities of ? - Lactone, Ester Group and Oxazinone Ring in Coumarin Derivatives Toward Carbon or Nitrogen Nucleophiles . A. F. El - Kafrawy, A. Y. Soliman, and H. M. Bakeer, F. K. Mohamed and M. Y. El – Kady, Chinese J. Chem. , 8 , ( 1990 ) , 469 – 473 .

Synthesis and Reactions of 4 – Aryl – 1 ( 2H ) – phthalazinones . M. A. Sayed, I. Islam, A. A. Mohamed, A. Y. Soliman and H. M. Bakeer, Chinese J. Chem. , 9 , ( 1991 ) , 45 – 53 .

Reaction with – 2 – Methyl – naphtho [1,2 – b] pyran – 4 – one and Related Substances . A. Y. Soliman, M. R. Mahmoud and H. M. Bakeer, Acta Chim. Hung., 128 ( 3 ) , ( 1991 ) , 345 – 354 .

Synthesis and Some Reactions of 7 – Methyl coumarin – 4 – acetic acid . A. Y. Soliman, A. F. El - Kafrawy, F. K. Mohamed and H. M. Bakeer and A. M. Abdel - Gawad, Indian J. Chem. , 30 ( B ) , ( 1991 ) , 477 – 481

Conversion of 2 – Arylhydrazono – 3 – oxobutyronitrile and 2– Phenylhydrazono – ethylbenzoylacetate into Heterocyclic Compounds . Hadeer M. Bakeer, J. Serb. Chem. Soc. , 57 ( 11 ) , ( 1992 ) , 725 – 730 .

Synthesis of Some Coumarin Derivatives and Study of their Behavior Towards Carbon and Nitrogen Nucleophiles . A. F. El - Kafrawy, A. Y. Soliman, H. M. Bakeer, F. K. Mohamed and A. M. Abdel - Gawad, Egyption J. Chem. , 35 ( 2 ) , ( 1992 ) , 253 – 263 .

Cycloaddation Reaction on Naphthopyran - 2 – one Derivatives . S. El – Nagdy, A. Y. Soliman, Hadeer M. Bakeer and A. M. Youssef J. Chem. Soc. Pakistan, 12 ( 3 ) , ( 1990 ) , 230 – 234 .

Synthesis and Reactions of 3 – Amino –6– [4– Chloro phenyl ] 6– hydro – 2 – mercaptodihydropyrimidine . F. K. Mohamed and H. M. Bakeer, Bull. Fac. Sci. , Assiut Univ, 24 ( 1 - B ) , ( 1995 ) , 311 – 324 .

Heterocyclic Compounds from 3 – (4 – Phenyl ) benozyl propionic acid . A. Y. Soliman, H. M. Bakeer and I. A. Attia, Chinese J. Chem. , 14 ( 6 ) , ( 1996 ) , 532 – 540 .

Electrochemical Analysis of Claisen Condensation of a Ferrocene Carrying Methylene – Active Side Chains with Oxo – Function Groups on Highly Ordered Pyrolytic Graphite . Hadeer M. Bakeer, R. R. Kassab and E. A. Kassab, Egypt. J. Chem. 46( 2 ) , ( 2003 ) , 285 – 295 .

Electrochemical Evidence for Detection of Steric Hindrance in 1- [2 – Cyclo hexyliden – 1 – one] – 2 – Ferrocenyl Ethylene . Contrasting Behavior in Solution and when Adsorbed on Highly Ordered Pyrolytic Graphite . Hadeer M. Bakeer, Egypt. J. Chem. 46 ( 3 ) , ( 2003 ) , 527 – 536 .

Conversion of 3 – Carbethoxy -4 – methyl Coumarin Derivatives into Several New Annelated Coumarin Derivatives . Hadeer M. Bakeer, Chinese J. Chem. , 21 , ( 2003 ) , 1219 – 1223 .

Synthesis and Some Reactions of Coumarin – 3 - yl Crotononitrile Derivatives . G. H. Tamam, H. M. Bakeer, R. M. Abdel – Motalab and W. A. Arafa, J. Chin. Chem. , Soc. , 52 ( 6 ) , ( 2005 ) , 1191 – 1199 .

Studies on 3 – ( Substituted ) Coumarin Derivatives Toward Different Electrophiles and Nucleophiles . H. M. Bakeer, International J. Chem. , 17 ( 3 ) , ( 2007 ) , 197 – 204 .

Synthesis and some reactions of 4-(2- alkayl-2- arylhydrazono) – 2 – phenyloxazol -5- one Derivatives . R. M. Abdel – Motalab, H. M. Bakeer, G. H. Tamam and W. A. A. Arafa, Egypt J. Chem. , 50 (6) , ( 2007 ) ,823-832 .

Synthesis of some interesting New Heterocyclic Compounds Containing Coumarin Moiety. H. M. Bakeer and F. K. Mohamed, Egypt J. Chem. , 51 (3) , ( 2008 ) , 325 – 335 .

Facile and preparation of 3- functional Chromen -2- ones . H. M. Bakeer, Egypt J. Chem., 51 (3) , ( 2008 ) , 401 – 411 .

Oxazole rearrangement, Heterofuntionalization of tetrahydrobenzo[b]- thiophene at position -2-incorporating 1,2,4-triazole moiety . H. M. Bakeer, R. M. Abdel- Motelab, G. H. Tamam and W. A. A. Araf, The 3rd International Conference of Chemical Industries Research Division,December 16 – 18, 2008, P101 .National Research Center, Cairo, Egypt .

Studies on 2-substituted 6,8-dihydro-4(H)-3,1-Benzoxazin-4-one . F. K. Mohamed and H. M. Bakeer and M. A. El- Hashash, Asian Journal of Chemistry, 21 (7) , ( 2009 ) , 5004 – 5014 .

Possible mechanism of acryl amide induced hormonal imbalance in adult male rats . Soha. M. Hamdy, H. M. Bakeer, Hanaa H. Ahmed, Emad F. Eskander and Ola N. Sayed, Journal of the Arab Society for Medical Research, 4 (1) , ( 2009 ) , 79 – 86 .

A Simple and Convenient Synthesis of 4-ylidene-5(4H)oxazolone Derivatives:Oxazolone Ring Transformation Leading to Other Heterocyclic Structures Ramadan M.Abdel-Motaleb, Hadeer M. Bakeer, Gammal H. Tamam, nd Wael A.A.Arafa. J.Heterocyclic Chem., 49 , 1071(2012).

Synthesis of novel heterocyclic compounds with special antimicrobial Activities from ?-(4-bromobenzoyl) acrylic acid Maher A.El-Hashash, Hadeer M.Bakeer, Fatehia.K.Mohammed, Haitham M.Hassan. under press.

Studies on 2- substituted 6.8- diploma-4 (H) – 3,1- binzoxazin – 4 – one F.K.Mohammud, H.M. Hadeer M.Bakeer and M.A.El- Hashash, Asion I. chem. 21,(7) (2009)5004- 5014.